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Alejandro Gonzalez Inarritu (AMORES PERROS) directs this staggeringly intense drama concerning three families whose lives fatefully intertwine through a series of tragic events. With jumbled chronology that jumps from one shocking event to the next in an increasingly chaotic maelstrom, 21 GRAMS is relentlessly gritty in its content and its aesthetics. The title refers to the amount of weight that a human body loses at the moment death arrives, but the story begs the question How much is gained